diff --git a/app/assets/javascripts/app/controllers/_ui_element/select.coffee b/app/assets/javascripts/app/controllers/_ui_element/select.coffee
index 01b0692a3..13a830dd4 100644
--- a/app/assets/javascripts/app/controllers/_ui_element/select.coffee
+++ b/app/assets/javascripts/app/controllers/_ui_element/select.coffee
@@ -35,8 +35,43 @@ class App.UiElement.select extends App.UiElement.ApplicationUiElement
     # filter attributes
     @filterOption(attribute, params)
 
+    item = $( App.view('generic/select')(attribute: attribute) )
+
+    # bind event listeners
+    @bindEventListeners(item, attribute, params)
+
     # return item
-    $( App.view('generic/select')(attribute: attribute) )
+    item
+
+  @bindEventListeners: (item, attribute, params) ->
+    if attribute.display_warn
+      item.bind('change', (e) =>
+        @bindWarnDisplayListener(e.target.value, attribute, params, item)
+      )
+
+      # initialization for default selection
+      @bindWarnDisplayListener(attribute.value, attribute, params, item)
+
+  @bindWarnDisplayListener: (selectedVal, attribute, params, item) ->
+    warn_visible = @shouldDisplayWarn(selectedVal, attribute, params)
+    @toggleDisplayWarn(warn_visible, attribute, item)
+
+  @shouldDisplayWarn: (selectedVal, attribute, params) ->
+    return if !selectedVal
+    return if !params
+    
+    params[attribute.name + '_is_display_warning'](selectedVal)
+
+  @toggleDisplayWarn: (warn_visible, attribute, item) ->
+    if !warn_visible
+      item.removeClass('display-warn')
+      item.find('.alert--warning').remove()
+      return
+
+    item.addClass('display-warn')
+    warn_elem = $('<div class="alert alert--warning" role="alert"></div>')
+    warn_elem.html(attribute.warn)
+    item.append(warn_elem)
 
   # 1. If attribute.value is not among the current options, then search within historical options
   # 2. If attribute.value is not among current and historical options, then add the value itself as an option
diff --git a/app/assets/javascripts/app/controllers/agent_ticket_create/form_handler_signature.coffee b/app/assets/javascripts/app/controllers/agent_ticket_create/form_handler_signature.coffee
index 3bf7d56cc..8b1c8f6f7 100644
--- a/app/assets/javascripts/app/controllers/agent_ticket_create/form_handler_signature.coffee
+++ b/app/assets/javascripts/app/controllers/agent_ticket_create/form_handler_signature.coffee
@@ -11,7 +11,7 @@ class TicketCreateFormHandlerSignature
 
     # check if signature needs to be added
     type = ui.el.closest('.content').find('[name="formSenderType"]').val()
-    if signature &&  signature.body && type is 'email-out'
+    if signature && signature.active && signature.body && type is 'email-out'
       signatureFinished = App.Utils.replaceTags(signature.body, { user: App.Session.get(), config: App.Config.all() })
 
       currentBody = ui.el.closest('.content').find('[data-name=body]')
diff --git a/app/assets/javascripts/app/controllers/ticket_zoom/article_action/email_reply.coffee b/app/assets/javascripts/app/controllers/ticket_zoom/article_action/email_reply.coffee
index f77657f0b..3140ef3a7 100644
--- a/app/assets/javascripts/app/controllers/ticket_zoom/article_action/email_reply.coffee
+++ b/app/assets/javascripts/app/controllers/ticket_zoom/article_action/email_reply.coffee
@@ -339,7 +339,7 @@ class EmailReply extends App.Controller
       signature = App.Signature.find(group.signature_id)
 
     # add/replace signature
-    if signature && signature.body
+    if signature && signature.active && signature.body
 
       # if signature has changed, remove it
       signature_id = ui.$('[data-signature=true]').data('signature-id')
diff --git a/app/assets/javascripts/app/models/group.coffee b/app/assets/javascripts/app/models/group.coffee
index 43f6448ef..43d50af87 100644
--- a/app/assets/javascripts/app/models/group.coffee
+++ b/app/assets/javascripts/app/models/group.coffee
@@ -9,7 +9,7 @@ class App.Group extends App.Model
     { name: 'follow_up_possible',   display: __('Follow-up possible'),tag: 'select', default: 'yes', options: { yes: 'yes', 'new_ticket': 'do not reopen Ticket but create new Ticket' }, null: false, note: __('Follow-up for closed ticket possible or not.'), translate: true },
     { name: 'follow_up_assignment', display: __('Assign follow-ups'), tag: 'select', default: 'yes', options: { true: 'yes', false: 'no' }, null: false, note: __('Assign follow-up to latest agent again.'), translate: true },
     { name: 'email_address_id',     display: __('Email'),             tag: 'select', multiple: false, null: true, relation: 'EmailAddress', nulloption: true, do_not_log: true },
-    { name: 'signature_id',         display: __('Signature'),         tag: 'select', multiple: false, null: true, relation: 'Signature', nulloption: true, do_not_log: true },
+    { name: 'signature_id',         display: __('Signature'),         tag: 'select', multiple: false, null: true, relation: 'Signature', nulloption: true, do_not_log: true, display_warn: true, warn: __('This signature is inactive, it won\'t be included in the reply. Change state <a href="#channels/email">here</a>') },
     { name: 'note',                 display: __('Note'),              tag: 'textarea', note: __('Notes are visible to agents only, never to customers.'), limit: 250, null: true },
     { name: 'updated_at',           display: __('Updated'),           tag: 'datetime', readonly: 1 },
     { name: 'active',               display: __('Active'),            tag: 'active', default: true },
@@ -43,3 +43,6 @@ class App.Group extends App.Model
     change: 'Change'
     overview: 'Overview'
     full: 'Full'
+
+  signature_id_is_display_warning: (signature_id) ->
+    !App.Signature.find(signature_id).active
diff --git a/app/assets/javascripts/app/views/generic/select.jst.eco b/app/assets/javascripts/app/views/generic/select.jst.eco
index d60ebcc05..bc0420544 100644
--- a/app/assets/javascripts/app/views/generic/select.jst.eco
+++ b/app/assets/javascripts/app/views/generic/select.jst.eco
@@ -1,12 +1,14 @@
 <div class="controls controls--select">
-  <select <% if @attribute.id: %>id="<%= @attribute.id %>"<% end %> class="form-control<%= " #{ @attribute.class }" if @attribute.class %>" name="<%= @attribute.name %>" <%= @attribute.multiple %> <%= @attribute.required %> <%= @attribute.autofocus %> <% if @attribute.disabled: %> disabled<% end %>>
-<% if @attribute.options: %>
-<% for row in @attribute.options: %>
-    <option value="<%= row.value %>" <%= row.selected %> <%= row.disabled %>><%= row.name %></option>
-<% end %>
-<% end %>
-  </select>
-  <% if not @attribute.multiple: %>
-    <%- @Icon('arrow-down') %>
-  <% end %>
+  <div class='relative'>
+    <select <% if @attribute.id: %>id="<%= @attribute.id %>"<% end %> class="form-control<%= " #{ @attribute.class }" if @attribute.class %>" name="<%= @attribute.name %>" <%= @attribute.multiple %> <%= @attribute.required %> <%= @attribute.autofocus %> <% if @attribute.disabled: %> disabled<% end %>>
+      <% if @attribute.options: %>
+        <% for row in @attribute.options: %>
+          <option value="<%= row.value %>" <%= row.selected %> <%= row.disabled %>><%= row.name %></option>
+        <% end %>
+      <% end %>
+    </select>
+    <% if not @attribute.multiple: %>
+      <%- @Icon('arrow-down') %>
+    <% end %>
+  </div>
 </div>
diff --git a/i18n/zammad.pot b/i18n/zammad.pot
index 252d5bd9d..fd47d198e 100644
--- a/i18n/zammad.pot
+++ b/i18n/zammad.pot
@@ -9016,6 +9016,10 @@ msgstr ""
 msgid "This service shows you contacts of incoming calls and a caller list in realtime."
 msgstr ""
 
+#: app/assets/javascripts/app/models/group.coffee
+msgid "This signature is inactive, it won't be included in the reply. Change state <a href=\"#channels/email\">here</a>"
+msgstr ""
+
 #: app/assets/javascripts/app/controllers/_application_controller/generic_history.coffee
 msgid "This ticket was merged into"
 msgstr ""
diff --git a/spec/system/manage/groups_spec.rb b/spec/system/manage/groups_spec.rb
index 703b30991..8608ff8eb 100644
--- a/spec/system/manage/groups_spec.rb
+++ b/spec/system/manage/groups_spec.rb
@@ -9,6 +9,35 @@ RSpec.describe 'Manage > Groups', type: :system do
     include_examples 'pagination', model: :group, klass: Group, path: 'manage/groups'
   end
 
+  # Fixes GitHub Issue#3129 - Deactivation of signature does not clear it from groups
+  describe 'When active status of signature assigned to a group is changed', authenticated_as: -> { user } do
+    let(:user)      { create(:admin, groups: [group]) }
+    let(:group)     { create(:group, signature_id: signature.id) }
+    let(:signature) { create(:signature) }
+
+    it 'does not display warning, when signature is active' do
+      visit '#manage/groups'
+
+      click "tr[data-id='#{group.id}']"
+
+      expect(page).to have_select('signature_id', selected: signature.name)
+        .and have_no_css('.alert--warning')
+    end
+
+    context 'When signature is marked inactive' do
+      let(:signature) { create(:signature, active: false) }
+
+      it 'displays warning' do
+        visit '#manage/groups'
+
+        click "tr[data-id='#{group.id}']"
+
+        expect(page).to have_select('signature_id', selected: signature.name)
+          .and have_css('.alert--warning')
+      end
+    end
+  end
+
   describe 'Core Workflow' do
     include_examples 'core workflow' do
       let(:object_name) { 'Group' }